Sapienza - Università di Roma
 Computer Science Department

PhD School

Borromini's Lantern (Saint Ivo at La Sapienza)

Advanced PhD level mini-courses

Spring 2018

Teacher: Blerina Sinaimeri (INRIA and LBBE, Lyon)

Dates: February 19, 20, 22

Time: 10:00 - 14:00

Room: Seminari

Title: Algorithmic aspects in genome and transcriptome assembly

Abstract: Next Generation Sequencing (NGS) methods have revolutionized genetics and at the same time have created many computationally challenging analysis problems. In particular nowadays sequencing is experiencing a major breakthrough with the advent of third generation sequencing, an emerging new technology represented by instruments commercialized by Pacific Biosciences and Oxford Nanopore Technologies (ONT) companies and bringing to light many new problems for computer scientists.
The goal of the course is to learn some computational methods -- algorithms and data structures -- for analyzing DNA and RNA sequencing data. We will start by learning a little about DNA and RNA. We'll learn a little bit about DNA sequencing technology, its past and present, and how it works. Some of the topics covered will be algorithms for de novo assembly, detection of transcriptomic variations and sequencing error correction.